Assay Detail
Binding
CHEMBL647562
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for inhibition of [3H]yohimbine against Alpha-2 adrenergic receptor from rat cortical membranes using in vitro adrenergic receptor binding assay.
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Substituted (pyrroloamino)pyridines: potential agents for the treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.31 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL29835 | BESIPIRDINE | 2.0 | 1 | 6.60 |
| CHEMBL350442 | — | — | 1 | 6.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL29835 | BESIPIRDINE | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL350442 | — | IC50 | = | 950.0 | nM | 6.02 |