Assay Detail
Binding
CHEMBL647613
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Binding affinity towards rat Alpha-1 adrenergic receptor was evaluated using [3H]- prazosin as radioligand
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Structure-activity relationship studies on the 5-HT(1A) receptor affinity of 1-phenyl-4-[omega-(alpha- or beta-tetralinyl)alkyl]piperazines. 4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 7.21 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2 | PRAZOSIN | 4.0 | 1 | 8.85 |
| CHEMBL26929 | — | — | 1 | 8.19 |
| CHEMBL322275 | — | — | 1 | 7.37 |
| CHEMBL147678 | — | — | 1 | 7.35 |
| CHEMBL148055 | — | — | 1 | 7.31 |
| CHEMBL342518 | — | — | 1 | 7.24 |
| CHEMBL444590 | — | — | 1 | 7.18 |
| CHEMBL144445 | — | — | 1 | 7.10 |
| CHEMBL143728 | — | — | 1 | 7.10 |
| CHEMBL144417 | — | — | 1 | 7.08 |
| CHEMBL357176 | — | — | 1 | 7.06 |
| CHEMBL343432 | — | — | 1 | 7.00 |
| CHEMBL147440 | — | — | 1 | 6.92 |
| CHEMBL341893 | — | — | 1 | 6.89 |
| CHEMBL145432 | — | — | 1 | 6.89 |
| CHEMBL143110 | — | — | 1 | 6.76 |
| CHEMBL172601 | — | — | 1 | 6.74 |
| CHEMBL147387 | — | — | 1 | 6.71 |
| CHEMBL49 | BUSPIRONE | 4.0 | 1 | - |
| CHEMBL56 | 8-OH-DPAT | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2 | PRAZOSIN | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL26929 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL322275 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL147678 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL148055 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL342518 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL444590 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL144445 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL143728 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL144417 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL357176 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL343432 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL147440 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL341893 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL145432 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL143110 | — | IC50 | = | 173.0 | nM | 6.76 |
| CHEMBL172601 | — | IC50 | = | 184.0 | nM | 6.74 |
| CHEMBL147387 | — | IC50 | = | 194.0 | nM | 6.71 |
| CHEMBL49 | BUSPIRONE | IC50 | > | 10000.0 | nM | - |
| CHEMBL56 | 8-OH-DPAT | IC50 | > | 10000.0 | nM | - |