Assay Detail
Binding
CHEMBL647614
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Binding affinity against Alpha-1 adrenergic receptor in rat brain membrane using [3H]prazosin as radioligand
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
1-aryl-4-[(1-tetralinyl)alkyl]piperazines: alkylamido and alkylamino derivatives. Synthesis, 5-HT1A receptor affinity, and selectivity. 3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.67 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2 | PRAZOSIN | 4.0 | 1 | 8.85 |
| CHEMBL26929 | — | — | 1 | 8.19 |
| CHEMBL111760 | — | — | 1 | 7.72 |
| CHEMBL322275 | — | — | 1 | 7.37 |
| CHEMBL444590 | — | — | 1 | 7.18 |
| CHEMBL28209 | — | — | 1 | 7.11 |
| CHEMBL110968 | — | — | 1 | 7.08 |
| CHEMBL28063 | — | — | 1 | 6.82 |
| CHEMBL108942 | — | — | 1 | 6.80 |
| CHEMBL26426 | — | — | 1 | 6.78 |
| CHEMBL108241 | — | — | 1 | 6.66 |
| CHEMBL321184 | — | — | 1 | 6.53 |
| CHEMBL108858 | — | — | 1 | 6.50 |
| CHEMBL324637 | — | — | 1 | 6.49 |
| CHEMBL320587 | — | — | 1 | 6.37 |
| CHEMBL325565 | — | — | 1 | 6.29 |
| CHEMBL323242 | — | — | 1 | 6.27 |
| CHEMBL325079 | — | — | 1 | 6.20 |
| CHEMBL108245 | — | — | 1 | 6.14 |
| CHEMBL325092 | — | — | 1 | 6.10 |
| CHEMBL107503 | — | — | 1 | 6.08 |
| CHEMBL107486 | — | — | 1 | 6.05 |
| CHEMBL326017 | — | — | 1 | 6.05 |
| CHEMBL107921 | — | — | 1 | 5.94 |
| CHEMBL109263 | — | — | 1 | 5.22 |
| CHEMBL56 | 8-OH-DPAT | — | 1 | - |
| CHEMBL49 | BUSPIRONE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2 | PRAZOSIN | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL26929 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL111760 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL322275 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL444590 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL28209 | — | IC50 | = | 78.3 | nM | 7.11 |
| CHEMBL110968 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL28063 | — | IC50 | = | 153.0 | nM | 6.82 |
| CHEMBL108942 | — | IC50 | = | 159.0 | nM | 6.80 |
| CHEMBL26426 | — | IC50 | = | 166.0 | nM | 6.78 |
| CHEMBL108241 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL321184 | — | IC50 | = | 297.0 | nM | 6.53 |
| CHEMBL108858 | — | IC50 | = | 313.0 | nM | 6.50 |
| CHEMBL324637 | — | IC50 | = | 327.0 | nM | 6.49 |
| CHEMBL320587 | — | IC50 | = | 427.0 | nM | 6.37 |
| CHEMBL325565 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL323242 | — | IC50 | = | 534.0 | nM | 6.27 |
| CHEMBL325079 | — | IC50 | = | 626.0 | nM | 6.20 |
| CHEMBL108245 | — | IC50 | = | 725.0 | nM | 6.14 |
| CHEMBL325092 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL107503 | — | IC50 | = | 838.0 | nM | 6.08 |
| CHEMBL107486 | — | IC50 | = | 881.0 | nM | 6.05 |
| CHEMBL326017 | — | IC50 | = | 887.0 | nM | 6.05 |
| CHEMBL107921 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL109263 | — | IC50 | = | 5980.0 | nM | 5.22 |
| CHEMBL56 | 8-OH-DPAT | IC50 | > | 10000.0 | nM | - |
| CHEMBL49 | BUSPIRONE | IC50 | > | 10000.0 | nM | - |