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Assay Detail

CHEMBL647624

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Compound was evaluated for beta adrenergic binding affinity towards beta-1 receptor of rat brain
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Beta-1 adrenergic receptor (CHEMBL3252)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Conformational effects on the activity of drugs. 13. A revision of previously proposed models for the activation of alpha- and beta-adrenergic receptors.
Macchia B, Balsamo A, Breschi MC, Lapucci A, Lucacchini A, Macchia F, Manera C, Martinelli A, Martini C, Martinotti E.
J Med Chem (1992) 35 : 1009 -1018
PubMed 1313109 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 2 4.57 4.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL7681 1 4.82
CHEMBL268881 1 4.32

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL7681 Ki = 15000.0 nM 4.82
CHEMBL268881 Ki = 48000.0 nM 4.32