Assay Detail
Binding
CHEMBL647676
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against rabbit lung angiotensin-1 converting enzyme
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Angiotensin-converting enzyme (CHEMBL4074) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Angiotensin-converting enzyme inhibitors. Mercaptan, carboxyalkyl dipeptide, and phosphinic acid inhibitors incorporating 4-substituted prolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.57 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL577 | ENALAPRILAT ANHYDROUS | 4.0 | 1 | 8.85 |
| CHEMBL581 | FOSINOPRILAT | 2.0 | 1 | 8.82 |
| CHEMBL1560 | CAPTOPRIL | 4.0 | 1 | 8.77 |
| CHEMBL277999 | — | — | 1 | 7.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL577 | ENALAPRILAT ANHYDROUS | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL581 | FOSINOPRILAT | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL1560 | CAPTOPRIL | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL277999 | — | Ki | = | 15.0 | nM | 7.82 |