Assay Detail
Binding
CHEMBL647678
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Angiotensin I converting enzyme from rabbit lungs at pH 7.5
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Angiotensin-converting enzyme (CHEMBL4074) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
N alpha-(diphenoxyphosphoryl)-L-alanyl-L-proline, N alpha-[bis (4-nitrophenoxy)phosphoryl]-L-alanyl-L-proline, and N alpha-[ (2-phenylethyl)phenoxyphosphoryl]-L-alanyl-L-proline: releasers of potent inhibitors of angiotensin converting enzyme at physiological pH and temperature.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 7.36 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34389 | — | — | 1 | 9.30 |
| CHEMBL30505 | — | — | 1 | 8.92 |
| CHEMBL30836 | — | — | 1 | 8.92 |
| CHEMBL286181 | — | — | 1 | 8.85 |
| CHEMBL282987 | — | — | 1 | 8.85 |
| CHEMBL34402 | — | — | 1 | 8.59 |
| CHEMBL33124 | — | — | 1 | 8.10 |
| CHEMBL33325 | — | — | 1 | 7.75 |
| CHEMBL33569 | — | — | 1 | 6.10 |
| CHEMBL282846 | — | — | 1 | 4.38 |
| CHEMBL414828 | — | — | 1 | 4.30 |
| CHEMBL30441 | — | — | 1 | 4.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34389 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL30505 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL30836 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL286181 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL282987 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL34402 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL33124 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL33325 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL33569 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL282846 | — | Ki | = | 42000.0 | nM | 4.38 |
| CHEMBL414828 | — | Ki | = | 50000.0 | nM | 4.30 |
| CHEMBL30441 | — | Ki | = | 55000.0 | nM | 4.26 |