Assay Detail
Binding
CHEMBL647722
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of 2-[(5-methylbenz-1-ox-4-azin-6-yl)imino]imidazoline, a potent, peripherally acting alpha 2 adrenoceptor agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.52 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL298936 | — | — | 1 | 8.92 |
| CHEMBL49137 | — | — | 1 | 8.70 |
| CHEMBL647 | APRACLONIDINE | 4.0 | 1 | 8.54 |
| CHEMBL134 | CLONIDINE | 4.0 | 1 | 8.42 |
| CHEMBL49284 | — | — | 1 | 8.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL298936 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL49137 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL647 | APRACLONIDINE | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL134 | CLONIDINE | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL49284 | — | Ki | = | 9.6 | nM | 8.02 |