Assay Detail
Binding
CHEMBL647723
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In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscine
28
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis of 3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazoles, displaying combined 5-HT uptake inhibiting and alpha(2)-adrenoceptor antagonistic activities: a novel series of potential antidepressants.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 28 | 8.02 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL419316 | — | — | 2 | 9.52 |
| CHEMBL91157 | — | — | 2 | 9.52 |
| CHEMBL90247 | — | — | 1 | 9.30 |
| CHEMBL422597 | — | — | 1 | 9.10 |
| CHEMBL93171 | — | — | 1 | 9.10 |
| CHEMBL90943 | — | — | 1 | 9.05 |
| CHEMBL92860 | — | — | 2 | 8.89 |
| CHEMBL327875 | — | — | 1 | 8.85 |
| CHEMBL268258 | — | — | 1 | 8.62 |
| CHEMBL328114 | — | — | 2 | 8.59 |
| CHEMBL94129 | — | — | 1 | 8.30 |
| CHEMBL90997 | — | — | 1 | 8.23 |
| CHEMBL93489 | — | — | 1 | 8.06 |
| CHEMBL328735 | — | — | 1 | 7.92 |
| CHEMBL328377 | — | — | 1 | 7.66 |
| CHEMBL420830 | — | — | 1 | 7.64 |
| CHEMBL90419 | — | — | 1 | 7.58 |
| CHEMBL91824 | — | — | 1 | 7.47 |
| CHEMBL93801 | — | — | 1 | 7.18 |
| CHEMBL94435 | — | — | 1 | 7.01 |
| CHEMBL90966 | — | — | 1 | 6.93 |
| CHEMBL90843 | — | — | 1 | 6.73 |
| CHEMBL92496 | — | — | 1 | 6.63 |
| CHEMBL91297 | — | — | 1 | 6.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL91157 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL419316 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL90247 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL422597 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL93171 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL90943 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL92860 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL327875 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL268258 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL328114 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL94129 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL90997 | — | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL93489 | — | Ki | = | 8.8 | nM | 8.06 |
| CHEMBL328735 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL91157 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL328377 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL420830 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL328114 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL90419 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL419316 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL91824 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL93801 | — | Ki | = | 66.0 | nM | 7.18 |
| CHEMBL92860 | — | Ki | = | 93.0 | nM | 7.03 |
| CHEMBL94435 | — | Ki | = | 98.0 | nM | 7.01 |
| CHEMBL90966 | — | Ki | = | 117.0 | nM | 6.93 |
| CHEMBL90843 | — | Ki | = | 186.0 | nM | 6.73 |
| CHEMBL92496 | — | Ki | = | 234.0 | nM | 6.63 |
| CHEMBL91297 | — | Ki | = | 234.0 | nM | 6.63 |