Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL90943

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
C(=C/c1ccccc1)\CN1CCN(CC2ON=C3c4ccccc4OCC32)CC1

Basic Information

ChEMBL ID CHEMBL90943
Phase Preclinical
Structure Type MOL
InChI Key MUUSOYWTPTTZII-RMKNXTFCSA-N
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

389.5
MW (Da)
3.13
ALogP
5
HBA
0
HBD
37.3
PSA (Ų)
0.79
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C24H27N3O2
MW 389.50
Aromatic Rings 2
Heavy Atoms 29
NP-Likeness -0.29

Activity Summary

Ki 4 meas. best 9.05

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Alpha-2A adrenergic receptor
CHEMBL1867
Ki 9.05 9.05 0.9 1
Alpha-2C adrenergic receptor
CHEMBL1916
Ki 8.77 8.77 1.7 1
Alpha-2B adrenergic receptor
CHEMBL1942
Ki 8.7 8.7 2.0 1
Sodium-dependent serotonin transporter
CHEMBL313
Ki 7.8 7.8 16.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
12873501 10.1016/s0960-894x(03)00525-0 Sodium-dependent serotonin transporter 2
12873501 10.1016/s0960-894x(03)00525-0 Alpha-2A adrenergic receptor 1
12873501 10.1016/s0960-894x(03)00525-0 Alpha-2B adrenergic receptor 1
12873501 10.1016/s0960-894x(03)00525-0 Alpha-2C adrenergic receptor 1
12873501 10.1016/s0960-894x(03)00525-0 Adrenergic receptor alpha-2 1

Data from ChEMBL 36 via Core Engine