Assay Detail
Binding
CHEMBL648625
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]rauwolscine
28
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis of 3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazoles, displaying combined 5-HT uptake inhibiting and alpha(2)-adrenoceptor antagonistic activities: a novel series of potential antidepressants.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 28 | 8.35 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL91157 | — | — | 2 | 10.00 |
| CHEMBL93171 | — | — | 1 | 9.70 |
| CHEMBL419316 | — | — | 2 | 9.70 |
| CHEMBL328114 | — | — | 2 | 9.30 |
| CHEMBL327875 | — | — | 1 | 9.22 |
| CHEMBL92860 | — | — | 2 | 9.10 |
| CHEMBL90943 | — | — | 1 | 8.77 |
| CHEMBL90419 | — | — | 1 | 8.72 |
| CHEMBL90247 | — | — | 1 | 8.72 |
| CHEMBL268258 | — | — | 1 | 8.68 |
| CHEMBL422597 | — | — | 1 | 8.64 |
| CHEMBL94129 | — | — | 1 | 8.51 |
| CHEMBL328377 | — | — | 1 | 8.33 |
| CHEMBL328735 | — | — | 1 | 8.28 |
| CHEMBL93489 | — | — | 1 | 8.21 |
| CHEMBL420830 | — | — | 1 | 8.02 |
| CHEMBL93801 | — | — | 1 | 7.89 |
| CHEMBL90997 | — | — | 1 | 7.72 |
| CHEMBL91824 | — | — | 1 | 7.52 |
| CHEMBL90966 | — | — | 1 | 7.44 |
| CHEMBL92496 | — | — | 1 | 7.05 |
| CHEMBL90843 | — | — | 1 | 7.05 |
| CHEMBL91297 | — | — | 1 | 7.05 |
| CHEMBL94435 | — | — | 1 | 7.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL91157 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL93171 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL419316 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL328114 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL327875 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL92860 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL91157 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL90943 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL90419 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL90247 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL268258 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL422597 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL94129 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL328377 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL328114 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL328735 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL93489 | — | Ki | = | 6.2 | nM | 8.21 |
| CHEMBL92860 | — | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL420830 | — | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL419316 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL93801 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL90997 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL91824 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL90966 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL90843 | — | Ki | = | 89.0 | nM | 7.05 |
| CHEMBL92496 | — | Ki | = | 89.0 | nM | 7.05 |
| CHEMBL91297 | — | Ki | = | 89.0 | nM | 7.05 |
| CHEMBL94435 | — | Ki | = | 89.0 | nM | 7.05 |