Assay Detail
Binding
CHEMBL647746
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Inhibition of human androgen receptor at 10e-12 to 10e-5 M
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
5-benzylidene-1,2-dihydrochromeno[3,4-f]quinolines as selective progesterone receptor modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.64 | 8.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL717 | MEDROXYPROGESTERONE ACETATE | 4.0 | 1 | 8.21 |
| CHEMBL103 | PROGESTERONE | 4.0 | 1 | 7.43 |
| CHEMBL132363 | — | — | 1 | 6.69 |
| CHEMBL134277 | — | — | 1 | 6.67 |
| CHEMBL336169 | — | — | 1 | 6.59 |
| CHEMBL134602 | — | — | 1 | 6.19 |
| CHEMBL336736 | — | — | 1 | 6.09 |
| CHEMBL413309 | — | — | 1 | 6.05 |
| CHEMBL336353 | — | — | 1 | 5.82 |
| CHEMBL335996 | — | — | 1 | - |
| CHEMBL130141 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL717 | MEDROXYPROGESTERONE ACETATE | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL103 | PROGESTERONE | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL132363 | — | IC50 | = | 203.0 | nM | 6.69 |
| CHEMBL134277 | — | IC50 | = | 215.0 | nM | 6.67 |
| CHEMBL336169 | — | IC50 | = | 258.0 | nM | 6.59 |
| CHEMBL134602 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL336736 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL413309 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL336353 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL335996 | — | IC50 | = | - | nM | - |
| CHEMBL130141 | — | IC50 | = | - | nM | - |