Assay Detail
Binding
CHEMBL647748
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against human Androgen receptor
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and biological activity of novel nonsteroidal progesterone receptor antagonists based on cyclocymopol monomethyl ether.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.90 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1276308 | MIFEPRISTONE | 4.0 | 1 | 8.30 |
| CHEMBL103 | PROGESTERONE | 4.0 | 1 | 7.43 |
| CHEMBL51639 | — | — | 1 | 6.62 |
| CHEMBL50023 | — | — | 1 | 6.60 |
| CHEMBL1908373 | ONAPRISTONE | 2.0 | 1 | 6.57 |
| CHEMBL417729 | — | — | 1 | 6.42 |
| CHEMBL51093 | — | — | 1 | 6.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1276308 | MIFEPRISTONE | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL103 | PROGESTERONE | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL51639 | — | IC50 | = | 238.0 | nM | 6.62 |
| CHEMBL50023 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL1908373 | ONAPRISTONE | IC50 | = | 269.0 | nM | 6.57 |
| CHEMBL417729 | — | IC50 | = | 377.0 | nM | 6.42 |
| CHEMBL51093 | — | IC50 | = | 449.0 | nM | 6.35 |