Assay Detail
Binding
CHEMBL647799
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Displacement of [125I]- Ang II from angiotensin II AT1 receptor in rat adrenal cortical microsomes
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Microsome |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Angiotensin II receptor (AT-1) type-1 (CHEMBL2094250) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Balanced angiotensin II receptor antagonists. I. The effects of biphenyl ortho-substitution on AT1/AT2 affinities
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 8.56 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL63998 | — | — | 1 | 9.52 |
| CHEMBL64411 | — | — | 1 | 9.22 |
| CHEMBL431162 | — | — | 1 | 9.15 |
| CHEMBL60942 | — | — | 1 | 9.00 |
| CHEMBL294512 | — | — | 1 | 9.00 |
| CHEMBL59331 | — | — | 1 | 8.70 |
| CHEMBL59611 | — | — | 1 | 8.70 |
| CHEMBL291582 | — | — | 1 | 8.70 |
| CHEMBL60992 | — | — | 1 | 8.70 |
| CHEMBL417393 | — | — | 1 | 8.70 |
| CHEMBL294578 | — | — | 1 | 8.70 |
| CHEMBL59957 | — | — | 1 | 8.62 |
| CHEMBL291803 | — | — | 1 | 8.52 |
| CHEMBL443269 | — | — | 1 | 8.52 |
| CHEMBL304022 | — | — | 1 | 8.52 |
| CHEMBL60661 | — | — | 1 | 8.52 |
| CHEMBL61168 | — | — | 1 | 8.52 |
| CHEMBL431137 | — | — | 1 | 8.22 |
| CHEMBL59728 | — | — | 1 | 8.15 |
| CHEMBL439936 | — | — | 1 | 8.15 |
| CHEMBL61754 | — | — | 1 | 8.00 |
| CHEMBL59974 | — | — | 1 | 7.70 |
| CHEMBL61976 | — | — | 1 | 7.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL63998 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL64411 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL431162 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL60942 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL294512 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL59331 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL59611 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL291582 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL60992 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL417393 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL294578 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL59957 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL291803 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL443269 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL304022 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL60661 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL61168 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL431137 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL59728 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL439936 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL61754 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL59974 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL61976 | — | IC50 | = | 40.0 | nM | 7.40 |