Assay Detail
Binding
CHEMBL647801
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity at Angiotensin II Type 1 receptor in rat liver membrane by [125I]AII displacement.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Liver |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Angiotensin II receptor (AT-1) type-1 (CHEMBL2094250) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Balanced AT1 and AT2 angiotensin II antagonists. II. Potent 5 -hydroxyacid imidazolyl biphenyl sulfonylureas
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 8.99 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL330744 | — | — | 1 | 9.70 |
| CHEMBL89769 | — | — | 1 | 9.70 |
| CHEMBL328480 | — | — | 1 | 9.70 |
| CHEMBL313073 | — | — | 1 | 9.52 |
| CHEMBL314506 | — | — | 1 | 9.40 |
| CHEMBL432378 | — | — | 1 | 9.30 |
| CHEMBL80370 | — | — | 1 | 9.30 |
| CHEMBL89463 | — | — | 1 | 9.30 |
| CHEMBL316021 | — | — | 1 | 9.30 |
| CHEMBL89053 | — | — | 1 | 9.22 |
| CHEMBL88446 | — | — | 1 | 9.15 |
| CHEMBL86617 | — | — | 1 | 9.00 |
| CHEMBL330302 | — | — | 1 | 8.89 |
| CHEMBL315327 | — | — | 1 | 8.60 |
| CHEMBL314827 | — | — | 1 | 8.55 |
| CHEMBL313005 | — | — | 1 | 8.54 |
| CHEMBL315275 | — | — | 1 | 8.42 |
| CHEMBL275449 | — | — | 1 | 8.41 |
| CHEMBL89052 | — | — | 1 | 8.32 |
| CHEMBL81236 | — | — | 1 | 8.20 |
| CHEMBL315994 | — | — | 1 | 8.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL330744 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL89769 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL328480 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL313073 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL314506 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL432378 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL80370 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL89463 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL316021 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL89053 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL88446 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL86617 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL330302 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL315327 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL314827 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL313005 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL315275 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL275449 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL89052 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL81236 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL315994 | — | IC50 | = | 6.6 | nM | 8.18 |