Assay Detail
Binding
CHEMBL647802
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In vitro binding affinity for rat liver angiotensin II receptor type 1, determined by displacement of the specially bound [3H]AII radioligand
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Angiotensin II receptor (AT-1) type-1 (CHEMBL2094250) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Synthesis and structure-activity relationship of a new series of potent AT1 selective angiotensin II receptor antagonists: 5-(biphenyl-4-ylmethyl)pyrazoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 7.59 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL153268 | — | — | 1 | 8.66 |
| CHEMBL907 | CARBOXYLIC ACID METABOLITE | — | 1 | 8.57 |
| CHEMBL152106 | — | — | 1 | 8.52 |
| CHEMBL153385 | — | — | 1 | 8.43 |
| CHEMBL345979 | — | — | 1 | 8.36 |
| CHEMBL357951 | — | — | 1 | 8.34 |
| CHEMBL153013 | — | — | 1 | 8.17 |
| CHEMBL356877 | — | — | 1 | 8.14 |
| CHEMBL436617 | — | — | 1 | 8.13 |
| CHEMBL152145 | — | — | 1 | 8.06 |
| CHEMBL154931 | — | — | 1 | 8.05 |
| CHEMBL443559 | — | — | 1 | 8.04 |
| CHEMBL153045 | — | — | 1 | 8.03 |
| CHEMBL153384 | — | — | 1 | 8.00 |
| CHEMBL422149 | — | — | 1 | 8.00 |
| CHEMBL358625 | — | — | 1 | 7.92 |
| CHEMBL434888 | — | — | 1 | 7.89 |
| CHEMBL153382 | — | — | 1 | 7.75 |
| CHEMBL153457 | — | — | 1 | 7.72 |
| CHEMBL153581 | — | — | 1 | 7.52 |
| CHEMBL151856 | — | — | 1 | 7.26 |
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 7.23 |
| CHEMBL433543 | — | — | 1 | 7.19 |
| CHEMBL358236 | — | — | 1 | 7.16 |
| CHEMBL435640 | — | — | 1 | 7.13 |
| CHEMBL151346 | — | — | 1 | 7.13 |
| CHEMBL358445 | — | — | 1 | 7.11 |
| CHEMBL358396 | — | — | 1 | 7.03 |
| CHEMBL153453 | — | — | 1 | 6.96 |
| CHEMBL419963 | — | — | 1 | 6.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL153268 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL907 | CARBOXYLIC ACID METABOLITE | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL152106 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL153385 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL345979 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL357951 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL153013 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL356877 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL436617 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL152145 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL154931 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL443559 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL153045 | — | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL153384 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL422149 | — | IC50 | = | 9.9 | nM | 8.00 |
| CHEMBL358625 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL434888 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL153382 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL153457 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL153581 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL151856 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL191 | LOSARTAN | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL433543 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL358236 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL435640 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL151346 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL358445 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL358396 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL153453 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL419963 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL150608 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL348705 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL440358 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL153340 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL356846 | — | IC50 | = | 770.0 | nM | 6.11 |