Assay Detail
Functional
CHEMBL647819
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Alpha-1 adrenergic receptor activation causing vasoconstriction in the isolated rabbit ear artery
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Artery |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
alpha-Adrenergic agents. 2. Synthesis and alpha 1-agonist activity of 2-aminotetralins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 23 | 6.69 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL280395 | — | — | 1 | 7.92 |
| CHEMBL30722 | — | — | 1 | 7.85 |
| CHEMBL283415 | — | — | 1 | 7.68 |
| CHEMBL30319 | — | — | 1 | 7.58 |
| CHEMBL30378 | — | — | 1 | 7.19 |
| CHEMBL30650 | — | — | 1 | 7.19 |
| CHEMBL31006 | — | — | 1 | 7.09 |
| CHEMBL31160 | — | — | 1 | 7.09 |
| CHEMBL21961 | — | — | 1 | 7.07 |
| CHEMBL30596 | — | — | 1 | 6.92 |
| CHEMBL283678 | — | — | 1 | 6.85 |
| CHEMBL1437 | NOREPINEPHRINE | 4.0 | 1 | 6.82 |
| CHEMBL283502 | — | — | 1 | 6.64 |
| CHEMBL30569 | — | — | 1 | 6.16 |
| CHEMBL524 | METHOXAMINE | 4.0 | 1 | 6.14 |
| CHEMBL30771 | — | — | 1 | 5.96 |
| CHEMBL26688 | — | — | 1 | 5.77 |
| CHEMBL30560 | — | — | 1 | 5.66 |
| CHEMBL286968 | — | — | 1 | 5.28 |
| CHEMBL31620 | — | — | 1 | 5.00 |
| CHEMBL31098 | — | — | 1 | - |
| CHEMBL30294 | — | — | 1 | - |
| CHEMBL31179 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL280395 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL30722 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL283415 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL30319 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL30378 | — | EC50 | = | 64.0 | nM | 7.19 |
| CHEMBL30650 | — | EC50 | = | 64.0 | nM | 7.19 |
| CHEMBL31006 | — | EC50 | = | 81.0 | nM | 7.09 |
| CHEMBL31160 | — | EC50 | = | 81.0 | nM | 7.09 |
| CHEMBL21961 | — | EC50 | = | 86.0 | nM | 7.07 |
| CHEMBL30596 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL283678 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL1437 | NOREPINEPHRINE | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL283502 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL30569 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL524 | METHOXAMINE | EC50 | = | 720.0 | nM | 6.14 |
| CHEMBL30771 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL26688 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL30560 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL286968 | — | EC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL31620 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL31098 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL30294 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL31179 | — | EC50 | > | 10000.0 | nM | - |