Assay Detail
Functional
CHEMBL647855
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Non-peptide angiotensin II receptor antagonists. 2. Design, synthesis, and biological activity of N-substituted (phenylamino)phenylacetic acids and acyl sulfonamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 5.52 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL337007 | — | — | 1 | 6.70 |
| CHEMBL335722 | — | — | 1 | 6.38 |
| CHEMBL135089 | — | — | 1 | 6.31 |
| CHEMBL336738 | — | — | 1 | 6.25 |
| CHEMBL336808 | — | — | 1 | 6.18 |
| CHEMBL135346 | — | — | 1 | 6.13 |
| CHEMBL135929 | — | — | 1 | 5.80 |
| CHEMBL134491 | — | — | 1 | 5.68 |
| CHEMBL134286 | — | — | 1 | 5.66 |
| CHEMBL337006 | — | — | 1 | 5.54 |
| CHEMBL135345 | — | — | 1 | 5.47 |
| CHEMBL336773 | — | — | 1 | 5.37 |
| CHEMBL335066 | — | — | 1 | 5.32 |
| CHEMBL135819 | — | — | 1 | 5.22 |
| CHEMBL335289 | — | — | 1 | 5.07 |
| CHEMBL337663 | — | — | 1 | 5.06 |
| CHEMBL135704 | — | — | 1 | 4.96 |
| CHEMBL424643 | — | — | 1 | 4.96 |
| CHEMBL334832 | — | — | 1 | 4.96 |
| CHEMBL132807 | — | — | 1 | 4.92 |
| CHEMBL424465 | — | — | 1 | 4.72 |
| CHEMBL335514 | — | — | 1 | 4.68 |
| CHEMBL7550 | L-158809 | — | 1 | - |
| CHEMBL136028 | — | — | 1 | - |
| CHEMBL335276 | — | — | 1 | - |
| CHEMBL136034 | — | — | 1 | - |
| CHEMBL191 | LOSARTAN | 4.0 | 1 | - |
| CHEMBL337217 | — | — | 1 | - |
| CHEMBL134754 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL337007 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL335722 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL135089 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL336738 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL336808 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL135346 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL135929 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL134491 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL134286 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL337006 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL135345 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL336773 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL335066 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL135819 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL335289 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL337663 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL135704 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL424643 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL334832 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL132807 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL424465 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL335514 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL7550 | L-158809 | IC50 | > | 10000.0 | nM | - |
| CHEMBL136028 | — | IC50 | > | 300.0 | nM | - |
| CHEMBL335276 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL136034 | — | IC50 | > | 110000.0 | nM | - |
| CHEMBL191 | LOSARTAN | IC50 | > | 30000.0 | nM | - |
| CHEMBL337217 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL134754 | — | IC50 | > | 10000.0 | nM | - |