Assay Detail
Binding
CHEMBL647875
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Binding affinity against human Beta-2 adrenergic receptor expressed in CHO cells using [125I]iodocyanopindolol
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Potent, selective 3-pyridylethanolamine beta3 adrenergic receptor agonists possessing a thiazole benzenesulfonamide pharmacophore.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.28 | 6.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL291992 | — | — | 1 | 6.21 |
| CHEMBL59270 | — | — | 1 | 6.04 |
| CHEMBL291593 | — | — | 1 | 6.00 |
| CHEMBL293994 | — | — | 1 | 5.77 |
| CHEMBL58798 | — | — | 1 | 5.72 |
| CHEMBL294753 | — | — | 1 | 5.70 |
| CHEMBL61429 | — | — | 1 | 5.70 |
| CHEMBL291594 | — | — | 1 | 5.68 |
| CHEMBL418308 | — | — | 1 | 5.64 |
| CHEMBL430594 | — | — | 1 | 5.60 |
| CHEMBL60281 | — | — | 1 | 5.52 |
| CHEMBL294492 | — | — | 1 | 5.52 |
| CHEMBL294172 | — | — | 1 | 5.52 |
| CHEMBL433248 | — | — | 1 | 5.40 |
| CHEMBL61962 | — | — | 1 | 5.24 |
| CHEMBL58407 | — | — | 1 | 5.20 |
| CHEMBL292598 | — | — | 1 | 5.10 |
| CHEMBL294849 | — | — | 1 | 4.80 |
| CHEMBL293577 | — | — | 1 | 4.33 |
| CHEMBL57908 | — | — | 1 | 4.31 |
| CHEMBL291516 | — | — | 1 | 4.30 |
| CHEMBL58241 | — | — | 1 | 4.05 |
| CHEMBL291306 | — | — | 1 | 4.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL291992 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL59270 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL291593 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL293994 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL58798 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL294753 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL61429 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL291594 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL418308 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL430594 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL60281 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL294492 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL294172 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL433248 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL61962 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL58407 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL292598 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL294849 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL293577 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL57908 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL291516 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL58241 | — | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL291306 | — | IC50 | = | 93000.0 | nM | 4.03 |