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Assay Detail

CHEMBL647878

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro affinity at Beta-2 adrenergic receptor in the presence of [125I]iodocyanopindolol.
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Beta-2 adrenergic receptor (CHEMBL210)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of L-755,507: a subnanomolar human beta 3 adrenergic receptor agonist.
Parmee ER, Ok HO, Candelore MR, Tota L, Deng L, Strader CD, Wyvratt MJ, Fisher MH, Weber AE.
Bioorg Med Chem Lett (1998) 8 : 1107 -1112
PubMed 9871717 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 23 6.46 6.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL417250 1 6.96
CHEMBL12939 1 6.96
CHEMBL275114 1 6.92
CHEMBL13132 1 6.89
CHEMBL13467 1 6.77
CHEMBL12998 L-755507 1 6.72
CHEMBL144870 1 6.70
CHEMBL13106 1 6.68
CHEMBL12943 1 6.66
CHEMBL268289 1 6.64
CHEMBL13453 1 6.64
CHEMBL274143 1 6.54
CHEMBL13459 1 6.46
CHEMBL13398 1 6.40
CHEMBL12911 1 6.40
CHEMBL13389 1 6.37
CHEMBL13068 1 6.35
CHEMBL275511 1 6.27
CHEMBL275291 1 6.16
CHEMBL274144 1 6.14
CHEMBL13521 1 6.00
CHEMBL273428 1 5.70
CHEMBL13432 1 5.30

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL417250 IC50 = 110.0 nM 6.96
CHEMBL12939 IC50 = 110.0 nM 6.96
CHEMBL275114 IC50 = 120.0 nM 6.92
CHEMBL13132 IC50 = 130.0 nM 6.89
CHEMBL13467 IC50 = 170.0 nM 6.77
CHEMBL12998 L-755507 IC50 = 190.0 nM 6.72
CHEMBL144870 IC50 = 200.0 nM 6.70
CHEMBL13106 IC50 = 210.0 nM 6.68
CHEMBL12943 IC50 = 220.0 nM 6.66
CHEMBL268289 IC50 = 230.0 nM 6.64
CHEMBL13453 IC50 = 230.0 nM 6.64
CHEMBL274143 IC50 = 290.0 nM 6.54
CHEMBL13459 IC50 = 350.0 nM 6.46
CHEMBL13398 IC50 = 400.0 nM 6.40
CHEMBL12911 IC50 = 400.0 nM 6.40
CHEMBL13389 IC50 = 430.0 nM 6.37
CHEMBL13068 IC50 = 450.0 nM 6.35
CHEMBL275511 IC50 = 540.0 nM 6.27
CHEMBL275291 IC50 = 700.0 nM 6.16
CHEMBL274144 IC50 = 720.0 nM 6.14
CHEMBL13521 IC50 = 1000.0 nM 6.00
CHEMBL273428 IC50 = 2000.0 nM 5.70
CHEMBL13432 IC50 = 5000.0 nM 5.30