Assay Detail
Binding
CHEMBL647886
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In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rat adrenal membrane
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Angiotensin II receptor (AT-1) type-1 (CHEMBL2094250) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Development of angiotensin II antagonists with equipotent affinity for human AT1 and AT2 receptor subtypes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 9.35 | 9.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL305647 | — | — | 1 | 9.96 |
| CHEMBL259843 | — | — | 1 | 9.89 |
| CHEMBL74556 | — | — | 1 | 9.85 |
| CHEMBL263452 | — | — | 1 | 9.85 |
| CHEMBL311160 | — | — | 1 | 9.85 |
| CHEMBL263191 | — | — | 1 | 9.77 |
| CHEMBL306362 | — | — | 1 | 9.64 |
| CHEMBL415073 | — | — | 1 | 9.60 |
| CHEMBL74442 | — | — | 1 | 9.52 |
| CHEMBL76821 | — | — | 1 | 9.41 |
| CHEMBL194608 | — | — | 1 | 9.30 |
| CHEMBL73876 | — | — | 1 | 9.30 |
| CHEMBL75401 | — | — | 1 | 9.24 |
| CHEMBL306361 | — | — | 1 | 9.19 |
| CHEMBL307430 | — | — | 1 | 9.19 |
| CHEMBL17487 | — | — | 1 | 9.18 |
| CHEMBL307290 | — | — | 1 | 8.89 |
| CHEMBL74144 | — | — | 1 | 8.89 |
| CHEMBL311386 | — | — | 1 | 8.70 |
| CHEMBL305956 | — | — | 1 | 8.64 |
| CHEMBL311484 | — | — | 1 | 8.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL305647 | — | IC50 | = | 0.11 | nM | 9.96 |
| CHEMBL259843 | — | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL74556 | — | IC50 | = | 0.14 | nM | 9.85 |
| CHEMBL263452 | — | IC50 | = | 0.14 | nM | 9.85 |
| CHEMBL311160 | — | IC50 | = | 0.14 | nM | 9.85 |
| CHEMBL263191 | — | IC50 | = | 0.17 | nM | 9.77 |
| CHEMBL306362 | — | IC50 | = | 0.23 | nM | 9.64 |
| CHEMBL415073 | — | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL74442 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL76821 | — | IC50 | = | 0.39 | nM | 9.41 |
| CHEMBL194608 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL73876 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL75401 | — | IC50 | = | 0.58 | nM | 9.24 |
| CHEMBL306361 | — | IC50 | = | 0.64 | nM | 9.19 |
| CHEMBL307430 | — | IC50 | = | 0.64 | nM | 9.19 |
| CHEMBL17487 | — | IC50 | = | 0.66 | nM | 9.18 |
| CHEMBL307290 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL74144 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL311386 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL305956 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL311484 | — | IC50 | = | 3.9 | nM | 8.41 |