Assay Detail
Binding
CHEMBL647973
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Alpha-2 adrenergic receptor binding affinity was tested against membrane preparations of rat brain using 0.2 nM [3H]rauwolscine as radioligand
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Medetomidine analogs as alpha 2-adrenergic ligands. 2. Design, synthesis, and biological activity of conformationally restricted naphthalene derivatives of medetomidine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.77 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL306751 | — | — | 1 | 7.89 |
| CHEMBL105328 | — | — | 1 | 7.48 |
| CHEMBL105487 | — | — | 1 | 6.91 |
| CHEMBL102076 | — | — | 1 | 6.78 |
| CHEMBL102669 | — | — | 1 | 5.83 |
| CHEMBL322844 | — | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL306751 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL105328 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL105487 | — | Ki | = | 122.0 | nM | 6.91 |
| CHEMBL102076 | — | Ki | = | 165.0 | nM | 6.78 |
| CHEMBL102669 | — | Ki | = | 1474.0 | nM | 5.83 |
| CHEMBL322844 | — | Ki | = | 1890.0 | nM | 5.72 |