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Assay Detail

CHEMBL647989

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of ALR2 (aldose reductase) of bovine lens
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bos taurus
Confidence 9 — Direct single protein target
Curated By Expert

Target

Aldo-keto reductase family 1 member B1 (CHEMBL3081)
Type SINGLE PROTEIN
Organism Bos taurus

Publication

1-Benzopyran-4-one antioxidants as aldose reductase inhibitors.
Costantino L, Rastelli G, Gamberini MC, Vinson JA, Bose P, Iannone A, Staffieri M, Antolini L, Del Corso A, Mura U, Albasini A.
J Med Chem (1999) 42 : 1881 -1893
PubMed 10354396 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 9 4.99 5.50

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL56890 1 5.50
CHEMBL56730 1 5.41
CHEMBL300814 FLAVANONE 1 5.40
CHEMBL301624 1 5.19
CHEMBL151 LUTEOLIN 2.0 1 5.02
CHEMBL294878 1 4.87
CHEMBL276915 7-HYDROXYFLAVONE 1 4.83
CHEMBL50 QUERCETIN 3.0 1 4.48
CHEMBL298539 1 4.22

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL56890 IC50 = 3140.0 nM 5.50
CHEMBL56730 IC50 = 3870.0 nM 5.41
CHEMBL300814 FLAVANONE IC50 = 3980.0 nM 5.40
CHEMBL301624 IC50 = 6520.0 nM 5.19
CHEMBL151 LUTEOLIN IC50 = 9570.0 nM 5.02
CHEMBL294878 IC50 = 13630.0 nM 4.87
CHEMBL276915 7-HYDROXYFLAVONE IC50 = 14650.0 nM 4.83
CHEMBL50 QUERCETIN IC50 = 32870.0 nM 4.48
CHEMBL298539 IC50 = 60490.0 nM 4.22