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Assay Detail

CHEMBL648024

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of partially purified calf lens aldose reductase; value ranges from 10E-4 to 10e-5 M
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bos taurus
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Aldo-keto reductase family 1 member B1 (CHEMBL3081)
Type SINGLE PROTEIN
Organism Bos taurus

Publication

Spiro hydantoin aldose reductase inhibitors.
Sarges R, Schnur RC, Belletire JL, Peterson MJ.
J Med Chem (1988) 31 : 230 -243
PubMed 3121857 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 4.00 4.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL312515 1 4.00
CHEMBL81106 1 4.00
CHEMBL79959 1 4.00
CHEMBL289431 1 4.00
CHEMBL80087 1 4.00
CHEMBL82548 1 4.00
CHEMBL419105 1 4.00
CHEMBL78662 1 4.00
CHEMBL289046 1 4.00
CHEMBL81605 1 4.00
CHEMBL78750 1 4.00
CHEMBL80088 1 4.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL312515 IC50 = 100000.0 nM 4.00
CHEMBL81106 IC50 = 100000.0 nM 4.00
CHEMBL79959 IC50 = 100000.0 nM 4.00
CHEMBL289431 IC50 = 100000.0 nM 4.00
CHEMBL80087 IC50 = 100000.0 nM 4.00
CHEMBL82548 IC50 = 100000.0 nM 4.00
CHEMBL419105 IC50 = 100000.0 nM 4.00
CHEMBL78662 IC50 = 100000.0 nM 4.00
CHEMBL289046 IC50 = 100000.0 nM 4.00
CHEMBL81605 IC50 = 100000.0 nM 4.00
CHEMBL78750 IC50 = 100000.0 nM 4.00
CHEMBL80088 IC50 = 100000.0 nM 4.00