Assay Detail
Binding
CHEMBL648029
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Binding affinity towards Alpha-1 adrenergic receptor from rat whole brain using [3H]prazosin (18.1 Ci/mmol,0.9nanoM)as radioligand
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Novel indolodioxanes with antihypertensive effects: potent ligands for the 5-HT1A receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 8.02 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL318374 | — | — | 1 | 9.22 |
| CHEMBL418802 | — | — | 1 | 8.74 |
| CHEMBL101535 | — | — | 1 | 8.22 |
| CHEMBL323088 | — | — | 1 | 8.06 |
| CHEMBL103983 | — | — | 1 | 7.94 |
| CHEMBL319023 | — | — | 1 | 7.91 |
| CHEMBL101483 | — | — | 1 | 7.70 |
| CHEMBL320880 | — | — | 1 | 7.53 |
| CHEMBL318166 | — | — | 1 | 7.52 |
| CHEMBL102175 | — | — | 1 | 7.40 |
| CHEMBL106283 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL318374 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL418802 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL101535 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL323088 | — | Ki | = | 8.8 | nM | 8.06 |
| CHEMBL103983 | — | Ki | = | 11.4 | nM | 7.94 |
| CHEMBL319023 | — | Ki | = | 12.3 | nM | 7.91 |
| CHEMBL101483 | — | Ki | = | 19.8 | nM | 7.70 |
| CHEMBL320880 | — | Ki | = | 29.4 | nM | 7.53 |
| CHEMBL318166 | — | Ki | = | 30.4 | nM | 7.52 |
| CHEMBL102175 | — | Ki | = | 39.6 | nM | 7.40 |
| CHEMBL106283 | — | Ki | > | 862.0 | nM | - |