Assay Detail
Binding
CHEMBL648038
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Evaluated for affinity at Alpha-1 adrenergic receptor of rat brain using [3H]prazosin as radioligand in radioligand binding assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis and pharmacological characterization of A-80426: A putative novel antidepressant combining -2 antagonism with 5-HT uptake inhibition
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.16 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL268258 | — | — | 1 | 6.96 |
| CHEMBL75342 | — | — | 1 | 6.62 |
| CHEMBL10347 | RAUWOLSCINE | — | 1 | 6.35 |
| CHEMBL41 | FLUOXETINE | 4.0 | 1 | 5.58 |
| CHEMBL490 | PAROXETINE | 4.0 | 1 | 5.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL268258 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL75342 | — | Ki | = | 241.0 | nM | 6.62 |
| CHEMBL10347 | RAUWOLSCINE | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL41 | FLUOXETINE | Ki | = | 2620.0 | nM | 5.58 |
| CHEMBL490 | PAROXETINE | Ki | = | 5320.0 | nM | 5.27 |