Assay Detail
Binding
CHEMBL648046
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In vitro binding affinity against alpha-1 adrenergic receptor of rat cerebral cortex using [3H]prazosin as radioligand.
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebral cortex |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of a new model of arylpiperazines. 2. Three-dimensional quantitative structure-activity relationships of hydantoin-phenylpiperazine derivatives with affinity for 5-HT1A and alpha 1 receptors. A comparison of CoMFA models.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 5.99 | 6.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL297844 | — | — | 1 | 6.87 |
| CHEMBL297887 | — | — | 1 | 6.54 |
| CHEMBL46471 | — | — | 1 | 6.30 |
| CHEMBL46672 | — | — | 1 | 6.06 |
| CHEMBL42881 | — | — | 1 | 5.92 |
| CHEMBL42654 | — | — | 1 | 5.68 |
| CHEMBL46470 | — | — | 1 | 5.59 |
| CHEMBL295244 | — | — | 1 | 5.48 |
| CHEMBL430567 | — | — | 1 | 5.48 |
| CHEMBL295527 | — | — | 1 | - |
| CHEMBL46862 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL297844 | — | Ki | = | 135.0 | nM | 6.87 |
| CHEMBL297887 | — | Ki | = | 292.0 | nM | 6.54 |
| CHEMBL46471 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL46672 | — | Ki | = | 869.0 | nM | 6.06 |
| CHEMBL42881 | — | Ki | = | 1193.0 | nM | 5.92 |
| CHEMBL42654 | — | Ki | = | 2075.0 | nM | 5.68 |
| CHEMBL46470 | — | Ki | = | 2588.0 | nM | 5.59 |
| CHEMBL295244 | — | Ki | = | 3296.0 | nM | 5.48 |
| CHEMBL430567 | — | Ki | = | 3296.0 | nM | 5.48 |
| CHEMBL295527 | — | Ki | = | 260000.0 | nM | - |
| CHEMBL46862 | — | Ki | = | 260000.0 | nM | - |