Assay Detail
Binding
CHEMBL648049
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Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligand
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebral cortex |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
alpha-Adrenergic activities of some substituted 2-(aminomethyl)imidazolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.12 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL597 | PHENTOLAMINE | 4.0 | 1 | 8.68 |
| CHEMBL51131 | — | — | 1 | 8.25 |
| CHEMBL51358 | — | — | 1 | 7.26 |
| CHEMBL300628 | — | — | 1 | 6.82 |
| CHEMBL300053 | — | — | 1 | 6.64 |
| CHEMBL49953 | — | — | 1 | 6.52 |
| CHEMBL51479 | — | — | 1 | 6.42 |
| CHEMBL541208 | — | — | 1 | 6.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL597 | PHENTOLAMINE | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL51131 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL51358 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL300628 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL300053 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL49953 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL51479 | — | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL541208 | — | Ki | = | 424.0 | nM | 6.37 |