Assay Detail
Binding
CHEMBL648055
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Evaluated for its ability to displace [3H]clonidine from alpha-2 adrenergic receptor of calf cerebral cortex
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebral cortex |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
N-(1,3,4,6,7,12b-hexahydro-2H-benzo[b]furo[2,3-a]quinolizin -2-yl)-N- methyl-2-hydroxyethane-sulfonamide: a potent and selective alpha 2-adrenoceptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.07 | 9.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL48603 | — | — | 1 | 9.11 |
| CHEMBL48558 | — | — | 1 | 8.87 |
| CHEMBL15245 | YOHIMBINE | 3.0 | 1 | 7.31 |
| CHEMBL299595 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL48603 | — | Ki | = | 0.77 | nM | 9.11 |
| CHEMBL48558 | — | Ki | = | 1.36 | nM | 8.87 |
| CHEMBL15245 | YOHIMBINE | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL299595 | — | Ki | = | 100.0 | nM | 7.00 |