Assay Detail
Functional
CHEMBL648070
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonistic activity against human androgen receptor (hAR) in CV-1 cells using cotransfection assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CV-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
4-Alkyl- and 3,4-dialkyl-1,2,3,4-tetrahydro-8-pyridono[5,6-g]quinolines: potent, nonsteroidal androgen receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.92 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL286684 | — | — | 1 | 7.92 |
| CHEMBL281028 | — | — | 1 | 7.80 |
| CHEMBL27297 | — | — | 1 | 7.70 |
| CHEMBL2113248 | — | — | 1 | 7.54 |
| CHEMBL2113247 | — | — | 1 | 7.20 |
| CHEMBL282866 | — | — | 1 | 7.14 |
| CHEMBL27413 | — | — | 1 | 6.67 |
| CHEMBL285602 | — | — | 1 | 6.60 |
| CHEMBL283449 | — | — | 1 | 6.59 |
| CHEMBL418198 | — | — | 1 | 5.57 |
| CHEMBL390728 | — | — | 1 | 5.34 |
| CHEMBL280865 | — | — | 1 | - |
| CHEMBL27769 | STANOLONE | 2.0 | 1 | - |
| CHEMBL27812 | — | — | 1 | - |
| CHEMBL431493 | — | — | 1 | - |
| CHEMBL27945 | — | — | 1 | - |
| CHEMBL27276 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL286684 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL281028 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL27297 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2113248 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL2113247 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL282866 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL27413 | — | IC50 | = | 216.0 | nM | 6.67 |
| CHEMBL285602 | — | IC50 | = | 251.0 | nM | 6.60 |
| CHEMBL283449 | — | IC50 | = | 259.0 | nM | 6.59 |
| CHEMBL418198 | — | IC50 | = | 2710.0 | nM | 5.57 |
| CHEMBL390728 | — | IC50 | = | 4580.0 | nM | 5.34 |
| CHEMBL280865 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL27769 | STANOLONE | IC50 | > | 10000.0 | nM | - |
| CHEMBL27812 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL431493 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL27945 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL27276 | — | IC50 | > | 10000.0 | nM | - |