Assay Detail
Functional
CHEMBL648071
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonistic activity against human androgen receptor (hAR) in CV-1 cells was determined as a function of maximal inhibition of dihydrotestosterone using cotransfection assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CV-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
4-Alkyl- and 3,4-dialkyl-1,2,3,4-tetrahydro-8-pyridono[5,6-g]quinolines: potent, nonsteroidal androgen receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.21 | 7.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL281945 | — | — | 1 | 7.21 |
| CHEMBL2113261 | — | — | 1 | - |
| CHEMBL282204 | — | — | 1 | - |
| CHEMBL27372 | — | — | 1 | - |
| CHEMBL282813 | — | — | 1 | - |
| CHEMBL25802 | — | — | 1 | - |
| CHEMBL436344 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL281945 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL2113261 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL282204 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL27372 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL282813 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL25802 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL436344 | — | IC50 | > | 10000.0 | nM | - |