Assay Detail
Binding
CHEMBL648097
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1B adrenergic receptor expressed in LTK cell
42
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cricetulus griseus |
| Cell Type | LTK |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Alpha-1B adrenergic receptor (CHEMBL3122) ↗| Type | SINGLE PROTEIN |
| Organism | Mesocricetus auratus |
Publication
Structure-activity studies for a novel series of tricyclic substituted hexahydrobenz[e]isoindole alpha(1A) adrenoceptor antagonists as potential agents for the symptomatic treatment of benign prostatic hyperplasia (BPH).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 42 | 7.98 | 9.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL291073 | — | — | 1 | 9.07 |
| CHEMBL290519 | — | — | 1 | 8.77 |
| CHEMBL41444 | — | — | 1 | 8.72 |
| CHEMBL288809 | — | — | 1 | 8.65 |
| CHEMBL289361 | — | — | 2 | 8.59 |
| CHEMBL2112073 | — | — | 2 | 8.58 |
| CHEMBL41234 | — | — | 1 | 8.52 |
| CHEMBL41344 | — | — | 1 | 8.51 |
| CHEMBL291154 | — | — | 1 | 8.50 |
| CHEMBL40754 | — | — | 1 | 8.48 |
| CHEMBL40650 | — | — | 1 | 8.47 |
| CHEMBL441032 | — | — | 1 | 8.43 |
| CHEMBL40310 | — | — | 1 | 8.37 |
| CHEMBL287965 | — | — | 1 | 8.33 |
| CHEMBL417890 | — | — | 1 | 8.27 |
| CHEMBL40780 | — | — | 1 | 8.21 |
| CHEMBL291262 | — | — | 1 | 8.21 |
| CHEMBL290388 | — | — | 1 | 8.20 |
| CHEMBL287928 | — | — | 1 | 8.18 |
| CHEMBL39037 | — | — | 1 | 8.16 |
| CHEMBL434591 | — | — | 1 | 8.11 |
| CHEMBL40819 | — | — | 1 | 8.07 |
| CHEMBL289758 | — | — | 1 | 8.00 |
| CHEMBL288530 | — | — | 1 | 7.90 |
| CHEMBL297218 | — | — | 1 | 7.87 |
| CHEMBL290243 | — | — | 1 | 7.86 |
| CHEMBL43573 | — | — | 1 | 7.84 |
| CHEMBL40564 | — | — | 1 | 7.84 |
| CHEMBL41155 | — | — | 1 | 7.84 |
| CHEMBL288678 | — | — | 1 | 7.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL291073 | — | Ki | = | 0.86 | nM | 9.07 |
| CHEMBL290519 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL41444 | — | Ki | = | 1.91 | nM | 8.72 |
| CHEMBL288809 | — | Ki | = | 2.25 | nM | 8.65 |
| CHEMBL289361 | — | Ki | = | 2.57 | nM | 8.59 |
| CHEMBL2112073 | — | Ki | = | 2.62 | nM | 8.58 |
| CHEMBL41234 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL41344 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL291154 | — | Ki | = | 3.15 | nM | 8.50 |
| CHEMBL40754 | — | Ki | = | 3.33 | nM | 8.48 |
| CHEMBL40650 | — | Ki | = | 3.39 | nM | 8.47 |
| CHEMBL289361 | — | Ki | = | 3.43 | nM | 8.46 |
| CHEMBL441032 | — | Ki | = | 3.73 | nM | 8.43 |
| CHEMBL40310 | — | Ki | = | 4.26 | nM | 8.37 |
| CHEMBL287965 | — | Ki | = | 4.63 | nM | 8.33 |
| CHEMBL417890 | — | Ki | = | 5.39 | nM | 8.27 |
| CHEMBL291262 | — | Ki | = | 6.12 | nM | 8.21 |
| CHEMBL40780 | — | Ki | = | 6.2 | nM | 8.21 |
| CHEMBL290388 | — | Ki | = | 6.34 | nM | 8.20 |
| CHEMBL287928 | — | Ki | = | 6.69 | nM | 8.18 |
| CHEMBL39037 | — | Ki | = | 6.95 | nM | 8.16 |
| CHEMBL434591 | — | Ki | = | 7.82 | nM | 8.11 |
| CHEMBL40819 | — | Ki | = | 8.49 | nM | 8.07 |
| CHEMBL289758 | — | Ki | = | 9.95 | nM | 8.00 |
| CHEMBL288530 | — | Ki | = | 12.5 | nM | 7.90 |
| CHEMBL297218 | — | Ki | = | 13.5 | nM | 7.87 |
| CHEMBL290243 | — | Ki | = | 13.9 | nM | 7.86 |
| CHEMBL2112073 | — | Ki | = | 14.01 | nM | 7.85 |
| CHEMBL40564 | — | Ki | = | 14.5 | nM | 7.84 |
| CHEMBL41155 | — | Ki | = | 14.3 | nM | 7.84 |
| CHEMBL43573 | — | Ki | = | 14.3 | nM | 7.84 |
| CHEMBL288678 | — | Ki | = | 15.5 | nM | 7.81 |
| CHEMBL40896 | — | Ki | = | 15.9 | nM | 7.80 |
| CHEMBL43234 | — | Ki | = | 23.8 | nM | 7.62 |
| CHEMBL289627 | — | Ki | = | 26.9 | nM | 7.57 |
| CHEMBL289166 | — | Ki | = | 35.8 | nM | 7.45 |
| CHEMBL43921 | — | Ki | = | 37.9 | nM | 7.42 |
| CHEMBL289437 | — | Ki | = | 61.6 | nM | 7.21 |
| CHEMBL43909 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL41332 | — | Ki | = | 119.0 | nM | 6.92 |
| CHEMBL41396 | — | Ki | = | 1220.0 | nM | 5.91 |
| CHEMBL296711 | — | Ki | = | 1853.0 | nM | 5.73 |