Assay Detail
Binding
CHEMBL648098
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Binding affinity against Alpha-1B adrenergic receptor from hamster clones.
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | hamster |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Alpha- and beta-adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 8.35 | 9.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL324090 | ABANOQUIL | 2.0 | 1 | 9.96 |
| CHEMBL2 | PRAZOSIN | 4.0 | 1 | 9.49 |
| CHEMBL10347 | RAUWOLSCINE | — | 1 | 9.22 |
| CHEMBL15245 | YOHIMBINE | 3.0 | 1 | 8.96 |
| CHEMBL709 | ALFUZOSIN | 4.0 | 1 | 7.92 |
| CHEMBL611 | TERAZOSIN | 4.0 | 1 | 7.52 |
| CHEMBL25554 | — | — | 1 | 7.43 |
| CHEMBL420060 | — | — | 1 | 6.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL324090 | ABANOQUIL | Ki | = | 0.11 | nM | 9.96 |
| CHEMBL2 | PRAZOSIN | Ki | = | 0.32 | nM | 9.49 |
| CHEMBL10347 | RAUWOLSCINE | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL15245 | YOHIMBINE | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL709 | ALFUZOSIN | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL611 | TERAZOSIN | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL25554 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL420060 | — | Ki | = | 535.0 | nM | 6.27 |