Assay Detail
Binding
CHEMBL648101
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Compound was tested for binding affinity against cloned Alpha-1B adrenergic receptor from hamster smooth muscle using radioligand ([3H]prazosin) binding assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cricetulus griseus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological profile of the enantiomers of [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-cis-octahydroquinoxalin- 1-yl]furan-2-ylmethanone (cyclazosin), a potent competitive alpha 1B- adrenoceptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.80 | 9.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL423294 | CYCLAZOSIN | — | 1 | 9.51 |
| CHEMBL2 | PRAZOSIN | 4.0 | 1 | 9.34 |
| CHEMBL97698 | — | — | 1 | 9.23 |
| CHEMBL342062 | — | — | 1 | 9.16 |
| CHEMBL267930 | SPIPERONE | 2.0 | 1 | 8.15 |
| CHEMBL140450 | — | — | 1 | 7.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL423294 | CYCLAZOSIN | Ki | = | 0.309 | nM | 9.51 |
| CHEMBL2 | PRAZOSIN | Ki | = | 0.4571 | nM | 9.34 |
| CHEMBL97698 | — | Ki | = | 0.5888 | nM | 9.23 |
| CHEMBL342062 | — | Ki | = | 0.6918 | nM | 9.16 |
| CHEMBL267930 | SPIPERONE | Ki | = | 7.079 | nM | 8.15 |
| CHEMBL140450 | — | Ki | = | 39.81 | nM | 7.40 |