Assay Detail
Binding
CHEMBL648111
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against Alpha-1B adrenergic receptor (recombinant human receptor) using [3H]prazosin.
26
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 4. Structure-activity relationship in the dihydropyrimidine series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 26 | 6.52 | 7.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL436407 | — | — | 1 | 7.47 |
| CHEMBL145587 | — | — | 1 | 7.17 |
| CHEMBL359421 | — | — | 1 | 7.03 |
| CHEMBL145746 | — | — | 1 | 7.00 |
| CHEMBL142981 | — | — | 1 | 6.85 |
| CHEMBL145770 | — | — | 1 | 6.85 |
| CHEMBL357842 | — | — | 1 | 6.80 |
| CHEMBL5483012 | — | — | 1 | 6.75 |
| CHEMBL141322 | — | — | 3 | 6.72 |
| CHEMBL357828 | — | — | 1 | 6.62 |
| CHEMBL145411 | — | — | 1 | 6.60 |
| CHEMBL144534 | — | — | 1 | 6.51 |
| CHEMBL144731 | — | — | 1 | 6.50 |
| CHEMBL141604 | — | — | 1 | 6.40 |
| CHEMBL145353 | — | — | 1 | 6.39 |
| CHEMBL357131 | — | — | 1 | 6.37 |
| CHEMBL145278 | — | — | 1 | 6.36 |
| CHEMBL145178 | — | — | 1 | 6.32 |
| CHEMBL145001 | — | — | 1 | 6.31 |
| CHEMBL142606 | — | — | 1 | 6.30 |
| CHEMBL358313 | — | — | 1 | 6.09 |
| CHEMBL142719 | — | — | 1 | 6.06 |
| CHEMBL342347 | — | — | 1 | 5.82 |
| CHEMBL359430 | — | — | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL436407 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL145587 | — | Ki | = | 67.0 | nM | 7.17 |
| CHEMBL359421 | — | Ki | = | 93.0 | nM | 7.03 |
| CHEMBL145746 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL142981 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL145770 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL357842 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL5483012 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL141322 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL357828 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL145411 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL144534 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL144731 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL141604 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL145353 | — | Ki | = | 410.0 | nM | 6.39 |
| CHEMBL357131 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL145278 | — | Ki | = | 440.0 | nM | 6.36 |
| CHEMBL141322 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL145178 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL145001 | — | Ki | = | 490.0 | nM | 6.31 |
| CHEMBL142606 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL141322 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL358313 | — | Ki | = | 810.0 | nM | 6.09 |
| CHEMBL142719 | — | Ki | = | 870.0 | nM | 6.06 |
| CHEMBL342347 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL359430 | — | Ki | = | 1700.0 | nM | 5.77 |