Assay Detail
Binding
CHEMBL648120
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Binding affinity against human Alpha-2b adrenergic receptor
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design and synthesis of novel dihydropyridine alpha-1a antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.17 | 6.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99864 | — | — | 1 | 6.62 |
| CHEMBL100045 | — | — | 1 | 6.54 |
| CHEMBL180561 | — | — | 1 | 6.38 |
| CHEMBL316495 | — | — | 1 | 6.29 |
| CHEMBL320736 | — | — | 1 | 6.12 |
| CHEMBL323579 | — | — | 1 | 6.04 |
| CHEMBL5483012 | — | — | 1 | 5.96 |
| CHEMBL95578 | — | — | 1 | 5.95 |
| CHEMBL95290 | — | — | 1 | 5.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99864 | — | Ki | = | 237.0 | nM | 6.62 |
| CHEMBL100045 | — | Ki | = | 288.0 | nM | 6.54 |
| CHEMBL180561 | — | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL316495 | — | Ki | = | 507.0 | nM | 6.29 |
| CHEMBL320736 | — | Ki | = | 753.0 | nM | 6.12 |
| CHEMBL323579 | — | Ki | = | 902.0 | nM | 6.04 |
| CHEMBL5483012 | — | Ki | = | 1088.0 | nM | 5.96 |
| CHEMBL95578 | — | Ki | = | 1131.0 | nM | 5.95 |
| CHEMBL95290 | — | Ki | = | 2541.0 | nM | 5.59 |