Assay Detail
Binding
CHEMBL648134
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Displacement of [3H]- flunitrazepam from rat GABA-A benzodiazepine receptor
13
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
GABA-A receptor; anion channel (CHEMBL1907607) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Antagonist, partial agonist, and full agonist imidazo[1,5-a]quinoxaline amides and carbamates acting through the GABAA/benzodiazepine receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 8.67 | 9.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL351822 | — | — | 1 | 9.24 |
| CHEMBL165458 | — | — | 1 | 9.16 |
| CHEMBL48418 | — | — | 2 | 9.15 |
| CHEMBL164243 | — | — | 1 | 9.12 |
| CHEMBL354385 | — | — | 1 | 9.11 |
| CHEMBL166874 | — | — | 1 | 8.85 |
| CHEMBL299133 | — | — | 1 | 8.82 |
| CHEMBL300633 | — | — | 1 | 8.72 |
| CHEMBL352974 | — | — | 1 | 8.40 |
| CHEMBL349876 | — | — | 1 | 8.18 |
| CHEMBL165194 | — | — | 1 | 8.17 |
| CHEMBL911 | ZOLPIDEM | 4.0 | 1 | 7.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL351822 | — | Ki | = | 0.58 | nM | 9.24 |
| CHEMBL165458 | — | Ki | = | 0.69 | nM | 9.16 |
| CHEMBL48418 | — | Ki | = | 0.71 | nM | 9.15 |
| CHEMBL164243 | — | Ki | = | 0.76 | nM | 9.12 |
| CHEMBL354385 | — | Ki | = | 0.77 | nM | 9.11 |
| CHEMBL166874 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL299133 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL300633 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL352974 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL349876 | — | Ki | = | 6.6 | nM | 8.18 |
| CHEMBL165194 | — | Ki | = | 6.7 | nM | 8.17 |
| CHEMBL48418 | — | Ki | = | 6.8 | nM | 8.17 |
| CHEMBL911 | ZOLPIDEM | Ki | = | 25.0 | nM | 7.60 |