Assay Detail
Binding
CHEMBL648161
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In vitro binding affinity determined for alpha-2 adrenergic receptor by the percentage displacement of [3H]- clonidine at 10e-6 M
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
2,4-Diamino-6,7-dimethoxyquinazolines. 2. 2-(4-Carbamoylpiperidino) derivatives as alpha 1-adrenoceptor antagonists and antihypertensive agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 7.06 | 7.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6789 | — | — | 1 | 7.27 |
| CHEMBL269537 | — | — | 1 | 7.27 |
| CHEMBL6766 | — | — | 1 | 7.26 |
| CHEMBL266927 | — | — | 1 | 7.25 |
| CHEMBL266317 | — | — | 1 | 7.25 |
| CHEMBL6481 | — | — | 1 | 7.21 |
| CHEMBL6424 | — | — | 1 | 7.21 |
| CHEMBL6556 | — | — | 1 | 7.20 |
| CHEMBL267457 | — | — | 1 | 7.19 |
| CHEMBL415288 | — | — | 1 | 7.17 |
| CHEMBL6474 | — | — | 1 | 7.15 |
| CHEMBL2 | PRAZOSIN | 4.0 | 1 | 5.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6789 | — | Ki | = | 53.9 | nM | 7.27 |
| CHEMBL269537 | — | Ki | = | 53.3 | nM | 7.27 |
| CHEMBL6766 | — | Ki | = | 54.8 | nM | 7.26 |
| CHEMBL266927 | — | Ki | = | 55.6 | nM | 7.25 |
| CHEMBL266317 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL6481 | — | Ki | = | 61.3 | nM | 7.21 |
| CHEMBL6424 | — | Ki | = | 62.1 | nM | 7.21 |
| CHEMBL6556 | — | Ki | = | 62.7 | nM | 7.20 |
| CHEMBL267457 | — | Ki | = | 64.7 | nM | 7.19 |
| CHEMBL415288 | — | Ki | = | 68.1 | nM | 7.17 |
| CHEMBL6474 | — | Ki | = | 71.4 | nM | 7.15 |
| CHEMBL2 | PRAZOSIN | Ki | = | 4830.0 | nM | 5.32 |