Assay Detail
Binding
CHEMBL648219
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The compound was evaluated for inhibition against Beta-lactamase derived from Staphylococcus aureus
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
The synthesis and evaluation of 2-substituted-7-(alkylidene)cephalosporin sulfones as beta-lactamase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.59 | 5.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1439 | TAZOBACTAM SODIUM | 4.0 | 1 | 5.59 |
| CHEMBL268919 | — | — | 1 | - |
| CHEMBL355571 | — | — | 1 | - |
| CHEMBL268632 | — | — | 1 | - |
| CHEMBL435467 | — | — | 1 | - |
| CHEMBL353004 | — | — | 1 | - |
| CHEMBL166730 | — | — | 1 | - |
| CHEMBL355246 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1439 | TAZOBACTAM SODIUM | IC50 | = | 2570.0 | nM | 5.59 |
| CHEMBL268919 | — | IC50 | = | 977000.0 | nM | - |
| CHEMBL355571 | — | IC50 | = | 230000.0 | nM | - |
| CHEMBL268632 | — | IC50 | = | 402000.0 | nM | - |
| CHEMBL435467 | — | IC50 | = | 102000.0 | nM | - |
| CHEMBL353004 | — | IC50 | = | 733000.0 | nM | - |
| CHEMBL166730 | — | IC50 | = | 1860000.0 | nM | - |
| CHEMBL355246 | — | IC50 | = | 844000.0 | nM | - |