Assay Detail
Binding
CHEMBL648268
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Inhibitory activity against rabbit lung angiotensin-converting enzyme(ACE)
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Angiotensin-converting enzyme (CHEMBL4074) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Kelatorphan and related analogs: potent and selective inhibitors of leukotriene A4 hydrolase
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.13 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL86201 | — | — | 1 | 6.70 |
| CHEMBL82343 | — | — | 1 | 4.70 |
| CHEMBL85430 | — | — | 1 | 4.70 |
| CHEMBL419305 | — | — | 1 | 4.40 |
| CHEMBL83291 | — | — | 1 | - |
| CHEMBL82898 | — | — | 1 | - |
| CHEMBL86211 | — | — | 1 | - |
| CHEMBL315255 | — | — | 1 | - |
| CHEMBL85542 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL86201 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL82343 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL85430 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL419305 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL83291 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL82898 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL86211 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL315255 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL85542 | — | IC50 | > | 100000.0 | nM | - |