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Assay Detail

CHEMBL648282

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Binding
Tested in vitro for inhibition of Angiotensin converting enzyme (ACE)
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Angiotensin-converting enzyme (CHEMBL1808)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Dual metalloprotease inhibitors. I. constrained peptidomimetics of mercaptoacyl dipeptides
Robl JA, Simpkins LM, Stevenson J, Sun C, Murugesan N, Barrish JC, Asaad MM, Bird J, Schaeffer TR, Trippodo NC, Petrillo EW, Karanewsky DS
Bioorg Med Chem Lett (1994) 4 : 1789 -1794
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 7.80 8.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL299181 1 8.40
CHEMBL51389 1 8.36
CHEMBL51498 1 8.32
CHEMBL299639 1 7.92
CHEMBL298388 1 7.89
CHEMBL53879 1 7.89
CHEMBL299441 1 7.85
CHEMBL51780 1 7.77
CHEMBL52733 1 7.75
CHEMBL54036 1 7.55
CHEMBL287896 1 7.52
CHEMBL301751 1 7.51
CHEMBL301364 1 7.44
CHEMBL50559 1 7.44
CHEMBL51438 1 7.44

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL299181 IC50 = 4.0 nM 8.40
CHEMBL51389 IC50 = 4.4 nM 8.36
CHEMBL51498 IC50 = 4.8 nM 8.32
CHEMBL299639 IC50 = 12.0 nM 7.92
CHEMBL298388 IC50 = 13.0 nM 7.89
CHEMBL53879 IC50 = 13.0 nM 7.89
CHEMBL299441 IC50 = 14.0 nM 7.85
CHEMBL51780 IC50 = 17.0 nM 7.77
CHEMBL52733 IC50 = 18.0 nM 7.75
CHEMBL54036 IC50 = 28.0 nM 7.55
CHEMBL287896 IC50 = 30.0 nM 7.52
CHEMBL301751 IC50 = 31.0 nM 7.51
CHEMBL301364 IC50 = 36.0 nM 7.44
CHEMBL50559 IC50 = 36.0 nM 7.44
CHEMBL51438 IC50 = 36.0 nM 7.44