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Assay Detail

CHEMBL648324

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity against GST-hARLBD was measured in SC-3 cell by using [3H]testosterone as radioligand
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type SC-3
Confidence 9 — Direct single protein target
Curated By Expert

Target

Androgen receptor (CHEMBL1871)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Anti-androgens with full antagonistic activity toward human prostate tumor LNCaP cells with mutated androgen receptor.
Ishioka T, Tanatani A, Nagasawa K, Hashimoto Y.
Bioorg Med Chem Lett (2003) 13 : 2655 -2658
PubMed 12873487 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 5.89 5.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL806 FLUTAMIDE 4.0 1 5.89

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL806 FLUTAMIDE Ki = 1300.0 nM 5.89