Assay Detail
Functional
CHEMBL648337
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against angiotensin converting enzyme (ACE)
133
Total Activities
126
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Three-dimensional quantitative structure-activity relationship of angiotesin-converting enzyme and thermolysin inhibitors. II. A comparison of CoMFA models incorporating molecular orbital fields and desolvation free energies based on active-analog and complementary-receptor-field alignment rules.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 133 | 7.20 | 9.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL35561 | — | — | 1 | 9.94 |
| CHEMBL35309 | — | — | 1 | 9.88 |
| CHEMBL80665 | — | — | 1 | 9.64 |
| CHEMBL78629 | — | — | 1 | 9.60 |
| CHEMBL35682 | — | — | 1 | 9.54 |
| CHEMBL284734 | — | — | 1 | 9.53 |
| CHEMBL285935 | — | — | 1 | 9.53 |
| CHEMBL286339 | — | — | 1 | 9.31 |
| CHEMBL34832 | — | — | 1 | 9.28 |
| CHEMBL289022 | — | — | 1 | 9.28 |
| CHEMBL312224 | — | — | 1 | 9.22 |
| CHEMBL34650 | — | — | 1 | 9.20 |
| CHEMBL431707 | — | — | 1 | 9.11 |
| CHEMBL33025 | — | — | 1 | 9.06 |
| CHEMBL284843 | — | — | 1 | 9.05 |
| CHEMBL310750 | — | — | 1 | 9.00 |
| CHEMBL284345 | — | — | 1 | 8.97 |
| CHEMBL80779 | — | — | 1 | 8.96 |
| CHEMBL1237 | LISINOPRIL ANHYDROUS | 4.0 | 1 | 8.92 |
| CHEMBL39538 | — | — | 1 | 8.92 |
| CHEMBL80906 | — | — | 1 | 8.77 |
| CHEMBL433442 | — | — | 1 | 8.72 |
| CHEMBL78346 | — | — | 1 | 8.66 |
| CHEMBL309308 | — | — | 1 | 8.66 |
| CHEMBL445561 | — | — | 1 | 8.59 |
| CHEMBL78340 | — | — | 1 | 8.59 |
| CHEMBL78726 | — | — | 1 | 8.55 |
| CHEMBL312431 | — | — | 1 | 8.54 |
| CHEMBL311268 | — | — | 1 | 8.54 |
| CHEMBL311363 | — | — | 1 | 8.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL35561 | — | IC50 | = | 0.1148 | nM | 9.94 |
| CHEMBL35309 | — | IC50 | = | 0.1318 | nM | 9.88 |
| CHEMBL80665 | — | IC50 | = | 0.2291 | nM | 9.64 |
| CHEMBL78629 | — | IC50 | = | 0.2512 | nM | 9.60 |
| CHEMBL35682 | — | IC50 | = | 0.2884 | nM | 9.54 |
| CHEMBL285935 | — | IC50 | = | 0.2951 | nM | 9.53 |
| CHEMBL284734 | — | IC50 | = | 0.2951 | nM | 9.53 |
| CHEMBL286339 | — | IC50 | = | 0.4898 | nM | 9.31 |
| CHEMBL34832 | — | IC50 | = | 0.5248 | nM | 9.28 |
| CHEMBL289022 | — | IC50 | = | 0.5248 | nM | 9.28 |
| CHEMBL312224 | — | IC50 | = | 0.6026 | nM | 9.22 |
| CHEMBL34650 | — | IC50 | = | 0.631 | nM | 9.20 |
| CHEMBL431707 | — | IC50 | = | 0.7762 | nM | 9.11 |
| CHEMBL33025 | — | IC50 | = | 0.871 | nM | 9.06 |
| CHEMBL284843 | — | IC50 | = | 0.8913 | nM | 9.05 |
| CHEMBL310750 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL284345 | — | IC50 | = | 1.072 | nM | 8.97 |
| CHEMBL80779 | — | IC50 | = | 1.096 | nM | 8.96 |
| CHEMBL39538 | — | IC50 | = | 1.202 | nM | 8.92 |
| CHEMBL1237 | LISINOPRIL ANHYDROUS | IC50 | = | 1.202 | nM | 8.92 |
| CHEMBL80906 | — | IC50 | = | 1.698 | nM | 8.77 |
| CHEMBL433442 | — | IC50 | = | 1.905 | nM | 8.72 |
| CHEMBL309308 | — | IC50 | = | 2.188 | nM | 8.66 |
| CHEMBL78346 | — | IC50 | = | 2.188 | nM | 8.66 |
| CHEMBL78340 | — | IC50 | = | 2.57 | nM | 8.59 |
| CHEMBL445561 | — | IC50 | = | 2.57 | nM | 8.59 |
| CHEMBL78726 | — | IC50 | = | 2.818 | nM | 8.55 |
| CHEMBL311268 | — | IC50 | = | 2.884 | nM | 8.54 |
| CHEMBL312431 | — | IC50 | = | 2.884 | nM | 8.54 |
| CHEMBL309941 | — | IC50 | = | 3.02 | nM | 8.52 |
| CHEMBL311363 | — | IC50 | = | 3.02 | nM | 8.52 |
| CHEMBL287518 | — | IC50 | = | 3.236 | nM | 8.49 |
| CHEMBL311757 | — | IC50 | = | 3.467 | nM | 8.46 |
| CHEMBL309962 | RENTIAPRIL | IC50 | = | 3.715 | nM | 8.43 |
| CHEMBL277270 | — | IC50 | = | 3.981 | nM | 8.40 |
| CHEMBL419649 | — | IC50 | = | 4.786 | nM | 8.32 |
| CHEMBL78731 | — | IC50 | = | 5.248 | nM | 8.28 |
| CHEMBL611148 | — | IC50 | = | 6.026 | nM | 8.22 |
| CHEMBL311471 | — | IC50 | = | 6.457 | nM | 8.19 |
| CHEMBL309601 | — | IC50 | = | 7.079 | nM | 8.15 |
| CHEMBL311525 | — | IC50 | = | 8.913 | nM | 8.05 |
| CHEMBL310841 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL420391 | — | IC50 | = | 12.02 | nM | 7.92 |
| CHEMBL430630 | — | IC50 | = | 12.02 | nM | 7.92 |
| CHEMBL435360 | — | IC50 | = | 12.02 | nM | 7.92 |
| CHEMBL78353 | — | IC50 | = | 15.14 | nM | 7.82 |
| CHEMBL35419 | — | IC50 | = | 15.85 | nM | 7.80 |
| CHEMBL79189 | — | IC50 | = | 19.95 | nM | 7.70 |
| CHEMBL1560 | CAPTOPRIL | IC50 | = | 22.91 | nM | 7.64 |
| CHEMBL78489 | — | IC50 | = | 34.67 | nM | 7.46 |