Assay Detail
Binding
CHEMBL648346
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Concentration required to inhibit the activity of Angiotensin I converting enzyme by 50%
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Novel synthesis of (S)-1-[5-(benzoylamino)-1,4-dioxo-6-phenylhexyl]-L-proline and analogues: potent angiotensin converting enzyme inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 7.15 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL172262 | — | — | 1 | 8.85 |
| CHEMBL173849 | — | — | 1 | 8.85 |
| CHEMBL435360 | — | — | 1 | 8.49 |
| CHEMBL173822 | — | — | 1 | 8.33 |
| CHEMBL176688 | — | — | 1 | 8.24 |
| CHEMBL1560 | CAPTOPRIL | 4.0 | 1 | 8.05 |
| CHEMBL172801 | — | — | 1 | 8.00 |
| CHEMBL172015 | — | — | 1 | 7.82 |
| CHEMBL368784 | — | — | 1 | 7.70 |
| CHEMBL366455 | — | — | 1 | 7.55 |
| CHEMBL172783 | — | — | 1 | 7.38 |
| CHEMBL173376 | — | — | 1 | 7.34 |
| CHEMBL177394 | — | — | 1 | 7.09 |
| CHEMBL172356 | — | — | 1 | 7.07 |
| CHEMBL368640 | — | — | 1 | 6.82 |
| CHEMBL369590 | — | — | 1 | 6.75 |
| CHEMBL176970 | — | — | 1 | 6.62 |
| CHEMBL172913 | — | — | 1 | 6.52 |
| CHEMBL172917 | — | — | 1 | 6.48 |
| CHEMBL172600 | — | — | 1 | 6.27 |
| CHEMBL366727 | — | — | 1 | 5.92 |
| CHEMBL176729 | — | — | 1 | 5.80 |
| CHEMBL369809 | — | — | 1 | 5.07 |
| CHEMBL556775 | — | — | 1 | 4.60 |
| CHEMBL177870 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL172262 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL173849 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL435360 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL173822 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL176688 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL1560 | CAPTOPRIL | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL172801 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL172015 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL368784 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL366455 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL172783 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL173376 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL177394 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL172356 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL368640 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL369590 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL176970 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL172913 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL172917 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL172600 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL366727 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL176729 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL369809 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL556775 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL177870 | — | IC50 | - | nM | - |