Assay Detail
Binding
CHEMBL648347
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Concentration required for 50% inhibition of Angiotensin I converting enzyme
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and angiotensin-converting enzyme inhibitory activity of 3-(Mercaptomethyl)-2-oxo-1-pyrrolidineacetic acids and 3-(Mercaptomethyl)-2-oxo-1-piperidineacetic acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.19 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1560 | CAPTOPRIL | 4.0 | 1 | 7.92 |
| CHEMBL11707 | — | — | 1 | 6.00 |
| CHEMBL11507 | — | — | 1 | 5.43 |
| CHEMBL12006 | — | — | 1 | 4.72 |
| CHEMBL416706 | — | — | 1 | 4.52 |
| CHEMBL11783 | — | — | 1 | 4.48 |
| CHEMBL416339 | — | — | 1 | 4.46 |
| CHEMBL11795 | — | — | 1 | 4.00 |
| CHEMBL12050 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1560 | CAPTOPRIL | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL11707 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL11507 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL12006 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL416706 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL11783 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL416339 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL11795 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL12050 | — | IC50 | - | nM | - |