Assay Detail
Binding
CHEMBL648423
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Displacement of [3H]prazosin from alpha-1 adrenergic receptor from rat brain cerebral cortex
9
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cerebral cortex |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Alpha-adrenoreceptor reagents. 4. Resolution of some potent selective prejunctional alpha 2-adrenoreceptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 5.96 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10332 | — | — | 3 | 7.57 |
| CHEMBL61325 | — | — | 3 | 6.54 |
| CHEMBL61234 | — | — | 3 | 5.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10332 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL10332 | — | Ki | = | 66.0 | nM | 7.18 |
| CHEMBL61325 | — | Ki | = | 285.0 | nM | 6.54 |
| CHEMBL61325 | — | Ki | = | 449.0 | nM | 6.35 |
| CHEMBL61234 | — | Ki | = | 1473.0 | nM | 5.83 |
| CHEMBL61234 | — | Ki | = | 1794.0 | nM | 5.75 |
| CHEMBL10332 | — | Ki | = | 6763.0 | nM | 5.17 |
| CHEMBL61325 | — | Ki | = | 13329.0 | nM | 4.88 |
| CHEMBL61234 | — | Ki | = | 46439.0 | nM | 4.33 |