Assay Detail
Binding
CHEMBL648453
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Inhibition of Angiotensin I converting enzyme
12
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Angiotensin-converting enzyme (CHEMBL4074) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
N-formyl hydroxylamine containing dipeptides: generation of a new class of vasopeptidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.87 | 8.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL177551 | — | — | 1 | 8.47 |
| CHEMBL90388 | — | — | 1 | 8.28 |
| CHEMBL89533 | — | — | 1 | 8.27 |
| CHEMBL289556 | OMAPATRILAT | 2.0 | 1 | 8.22 |
| CHEMBL42583 | SAMPATRILAT | 2.0 | 1 | 8.15 |
| CHEMBL89563 | — | — | 1 | 7.60 |
| CHEMBL89760 | — | — | 2 | 7.03 |
| CHEMBL314626 | — | — | 1 | 6.97 |
| CHEMBL2370089 | — | — | 1 | - |
| CHEMBL315395 | — | — | 1 | - |
| CHEMBL88228 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL177551 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL90388 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL89533 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL289556 | OMAPATRILAT | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL42583 | SAMPATRILAT | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL89563 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL89760 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL314626 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL2370089 | — | IC50 | = | 228000.0 | nM | - |
| CHEMBL315395 | — | IC50 | = | 529000.0 | nM | - |
| CHEMBL88228 | — | IC50 | = | 461000.0 | nM | - |
| CHEMBL89760 | — | IC50 | = | 210000.0 | nM | - |