Assay Detail
Binding
CHEMBL648485
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In vivo inhibitory activity against Angiotensin I converting enzyme was evaluated in renal hypertensive rats
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological activity of carboxylic acid replacement analogues of the potent angiotensin converting enzyme inhibitor 5(S)-benzamido-4-oxo-6-phenylhexanoyl-L-proline.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.87 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428883 | — | — | 1 | 7.66 |
| CHEMBL1560 | CAPTOPRIL | 4.0 | 1 | 7.64 |
| CHEMBL10962 | — | — | 1 | 6.70 |
| CHEMBL274068 | — | — | 1 | 6.58 |
| CHEMBL274333 | — | — | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428883 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL1560 | CAPTOPRIL | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL10962 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL274068 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL274333 | — | IC50 | = | 1700.0 | nM | 5.77 |