Assay Detail
Binding
CHEMBL648488
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Inhibitory concentration against Angiotensin II receptor type 1 with [125I]-[Sar1,Ile8]Ang II
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Angiotensin II receptor (AT-1) type-1 (CHEMBL2094250) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Balanced AT1/AT2 receptor antagonists. 4. XR510 and related 5-(3-amidopropanoyl)imidazoles possessing equal affinity for the AT1 and AT2 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 9.95 | 10.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL60942 | — | — | 1 | 10.05 |
| CHEMBL294512 | — | — | 1 | 10.00 |
| CHEMBL304022 | — | — | 1 | 9.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL60942 | — | IC50 | = | 0.09 | nM | 10.05 |
| CHEMBL294512 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL304022 | — | IC50 | = | 0.16 | nM | 9.80 |