Assay Detail
Binding
CHEMBL648529
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Inhibition of Angiotensin I converting enzyme
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Excursions in drug discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.69 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1237 | LISINOPRIL ANHYDROUS | 4.0 | 1 | 8.92 |
| CHEMBL577 | ENALAPRILAT ANHYDROUS | 4.0 | 1 | 8.92 |
| CHEMBL152758 | — | — | 1 | 7.05 |
| CHEMBL358439 | — | — | 1 | 5.62 |
| CHEMBL62678 | — | — | 1 | 5.31 |
| CHEMBL291381 | — | — | 1 | 4.30 |
| CHEMBL293213 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1237 | LISINOPRIL ANHYDROUS | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL577 | ENALAPRILAT ANHYDROUS | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL152758 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL358439 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL62678 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL291381 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL293213 | — | IC50 | = | 260000.0 | nM | - |