Assay Detail
Binding
CHEMBL648567
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Displacement of [125I]- Ang II from type 1 Angiotensin II receptor
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Type-1 angiotensin II receptor A (CHEMBL329) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Imidazolinones as nonpeptide angiotensin II receptor antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 8.09 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1513 | IRBESARTAN | 4.0 | 1 | 9.05 |
| CHEMBL39379 | — | — | 1 | 9.05 |
| CHEMBL286134 | — | — | 1 | 9.00 |
| CHEMBL39996 | — | — | 1 | 9.00 |
| CHEMBL290180 | — | — | 1 | 8.52 |
| CHEMBL39352 | — | — | 1 | 8.52 |
| CHEMBL290614 | — | — | 1 | 8.52 |
| CHEMBL37892 | — | — | 1 | 8.40 |
| CHEMBL435953 | — | — | 1 | 8.10 |
| CHEMBL36324 | — | — | 1 | 8.05 |
| CHEMBL37768 | — | — | 1 | 7.70 |
| CHEMBL39978 | — | — | 1 | 7.00 |
| CHEMBL38161 | — | — | 1 | 6.52 |
| CHEMBL39542 | — | — | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1513 | IRBESARTAN | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL39379 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL286134 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL39996 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL290180 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL39352 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL290614 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL37892 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL435953 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL36324 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL37768 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL39978 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL38161 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL39542 | — | IC50 | = | 1400.0 | nM | 5.85 |